Uncertainty Factor:

One of several, generally 10-fold factors, used in operationally deriving the Reference Dose (RfD) from experimental data. UFs are intended to account for (1) the variation in sensitivity among the members of the human population; (2) the uncertainty in extrapolating animal data to the case of humans; (3) the uncertainty in extrapolating from data obtained in a study that is of less-than-lifetime exposure; and (4) the uncertainty in using LOAEL data rather than NOAEL data.

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